Netherlands Discussion Group
The Netherlands Area Biotech (NLab) Discussion Group enables the local area community of industry, academic, and regulatory professionals to meet and share ideas and experiences, thereby working together to resolve scientific challenges in the field of biopharmaceutical development and regulation.
The NLab Discussion Group goals include:
- Share learning across industry, academia, and health authorities in Europe in general, and in the Netherlands in particular.
- Generate new scientific and technical insights and solutions for developing biopharmaceutical products in the future.
- Contribute to the expansion of CASSS’ mission, vision, influence, and community in Europe.
Click on the sections below for detailed information:
Process Analytical Technologies | 25 November 2025 18:00-21:00 | Leiden, Netherlands
Join us on 25 November for an in-person program featuring presentations on process analytical technologies from the academic, industry, and regulatory perspectives. This opportunity is FREE to our members. Register by 21 November 2025.
Location:
Leiden University Medical Center
Albinusdreef 22333 ZA K-01-084 | CZ 4 | R762, Gebouw 01
Attendance and Substitution Policy
CASSS reserves the right to withdraw, replace, add, or substitute presenters, speakers, and other guests without notice. Entry into the conference is at the sole discretion of CASSS and CASSS reserves the right to refuse entry to anyone for any reason.
Process Analytical Techniques (PAT) in Biopharmaceutical Processes | Michel Eppink
Biopharmaceutical proteins (e.g. monoclonal antibodies) are important therapeutic medicines for different human diseases such as oncology (e.g. breast cancer, lung cancer) and infectious diseases (e.g. Crohn’s disease). These complex biomolecules are generated in biotechnological processes using Chinese Hamster Ovary (CHO) cell lines able to mimic these proteins in such a way that humans are able to use these medicines without immunogenicity problems. Upstream Processing (USP) expresses the proteins to high yield whereas Downstream Processing (DSP) purifies the expressed proteins and formulates it for use as medicine in patients as a solution or as a freeze dried product. These USP and DSP processes are mostly operated batch wise in clearly defined unit operations, however, the developed processes are labor intensive, take much time, product losses and produce a lot of waste. Continuous processing would be a solution to improve the overall process so that more consistent results are obtained, lower overall cost price and the process can be performed in closed operations preventing infections (e.g. bacteria, fungi, yeast). To perform these continuous processes monitoring of Critical Quality Attributes (CQAs) is key to follow the process in-line, at-line, on-line and off-line. In this presentation different techniques will be discussed how biopharmaceutical processes can be monitored and follow the progress during the processing of the different unit operations.
In-line Raman Spectroscopy for Process Characterization | Marieke Klijn
In-line Raman spectroscopy is increasingly applied as a process analytical technology to enable real-time monitoring of key process parameters and product quality attributes. This talk will cover how and where Raman spectroscopy is currently applied in bioprocess characterization, what hurdles still need to be overcome, and how different calibration methods are used to speed up its implementation.
Michel Eppink
Byondis BV
Michel Eppink received his MSc. in biology/chemistry in 1993 from the University of Utrecht and his PhD in Biochemistry in 1999 from the Wageningen University. After that starting at Organon NV becoming Section Manager Downstream Processing Research. In 2009 Eppink moved to Byondis BV (formerly known as Synthon) and currently Senior Director Process Development.
From 2014 - 2024 he was Professor (part-time) at Bioprocess Engineering of Wageningen University and Research. In 2024 Eppink started as Professor (part-time) at the Department of Biotechnology of TU Delft with focus on Industrial Biopharmaceutical Downstream Processing integrating Upstream and Downstream Processing.
Eppink has over 35 years of experience in biopharmaceutical processing of large biomolecules.
Marieke Klijn
Delft University of Technology
After earning a MSc in Biochemical Engineering and a PhD in protein analytics and machine learning, Klijn established a research group in 2020 at Delft University of Technology with a focus on applying advanced analytics to understand, develop, and control bioprocesses. The topics in her research group range from microbial fermentation to ATMP production, where synergy is found in the application of in-line analytics, development of technology to speed up data-driven modelling, and work towards data-driven control strategies.
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Register Now
Save your spot for the virtual Netherlands Area Biotech (NLab) Discussion Group on 25 November 2025. Register for in-person attendance by 21 November 2025.
