Higher Order Structure 

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International Symposium on the Higher Order Structure of Protein Therapeutics

Protein higher-order structure (HOS) and dynamics are essential to protein function. For protein-based therapeutic products, HOS is a critical quality attribute which needs to be monitored to ensure safety and efficacy of drug products. HOS can be monitored by a multitude of biophysical and structural characterization tools. The choice of the appropriate biophysical method and the method development and qualification strategies to characterize and control HOS at different stages of the product lifecycle are a matter of interest and debate for a wide range of audiences.

Reasons to Attend HOS:

  • Phase-appropriate application of biophysical methods for HOS characterization during development, comparability, or biosimilarity exercises
  • The theory and practice of biophysics and the application of HOS in a molecular discovery setting
  • HOS case studies from academia, government agencies, and industry
  • Biophysical method qualification, validation, and specification-setting strategies
  • HOS characterization of new modalities (adeno-associated viruses, bioconjugates, bispecific antibodies, etc...)

For more information, contact Dave Bergeson.


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Access approved content from past meetings in the NEW CASSS On Demand platform. CASSS members have access to all available presentation recordings starting in April 2020. Visit https://ondemand.casss.org, login to your account, and select from the list of meetings to begin.

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Thank You for Joining Us

We appreciate your participation in Higher Order Structure (HOS) 2023 on September 6-7, 2023.

Image of turquoise with text 'HOS Because Structure Matters September 6-7 Chicago, IL'

Review Resources

Want to revisit a keynote presentation? Missed important details that may impact your work?

Visit Papers and Presentations to access relevant presentations, summary papers, and roundtable notes.