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Mass Spec 2016: Roundtable Discussion Notes
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Table 1: Multi-attribute Methods (MAM)
Facilitator: Rich Rogers, Just. Biotherapeutics 
Scribe: Catherine Eakin, Seattle Genetics, Inc.

To view notes from this discussion, click here 

 


 

Table 2: Native Mass Spectrometry and its use in Biopharmaceutical Protein Characterization
Facilitator: David Passmore, Bristol-Myers Squibb Company 
Scribe 
Olga Friese, Pfizer, Inc.

To view notes from this discussion, click here 

 


 

Table 3: Ion Mobility MS and its use in Biopharmaceutical Protein Characterization 
Facilitator: Scott Berger, Waters Corporation 
Scribe: James Carroll, Pfizer, Inc.

To view notes from this discussion, click here  

 

 

Table 4: Sample Preparation – Consistency, Efficiency, Robustness: How to Optimize
Facilitator: Trina Formolo, NIST 
Scribe: Jason Hogan, Bristol-Myers Squibb Company

To view notes from this discussion, click here  

 


 

Table 5: Best Practices for Quantifying Proteoforms in Peptide Maps
Facilitator:  John Valliere-Douglass, Seattle Genetics, Inc.
Scribe: Benjamin Moore, Genentech, a Member of the Roche Group 

To view notes from this discussion, click here  

 


 

Table 6: Higher-order Structure Analysis by MS
Facilitator: Vivian Lindo, MedImmune, A member of the AstraZeneca Group 
Scribe: Carly Daniels, Pfizer, Inc. 

To view notes from this discussion, click here  

 


 

Table 7: The Do's and Don’ts for MS Data Deconvolution and Quantitation Based on Intact Protein Data
Facilitator: Aaron Bailey, Thermo FIsher Scientific
Scribe: Jason Rouse, Pfizer, Inc. 

To view notes from this discussion, click here  

 

 

Table 8: Qualification/Validation of MS-based Characterization Methods for use in a Regulated Environment
Facilitator: 
Alain Balland, Boehringer Ingelheim Pharma GmbH & Co, KG 
Scribe: John Schiel, NIST

To view notes from this discussion, click here  

 

 

Table 9: Best Practices for Host Cell Protein Analysis using MS
Facilitator: Ying ZhangPfizer, Inc. 
Scribe: Sean McCarthy, SCIEX

To view notes from this discussion, click here  

 


 

Table 10: Quantitation Differences Across Instrument Platforms
Facilitator: Anders Lund, Genzyme, a Sanofi company 
Scribe: StJohn Skilton, Protein Metrics Inc. 

To view notes from this discussion, click here 

 


 

Table 11: Maximizing the Benefit of Stable Isotope-labeled Internal Standards
Facilitator: Steven Cohen, Northeastern University 
Scribe: Wenzhou Li, Amgen, Inc. 

 To view notes from this discussion, click here.

 


 

Table 12: Mass Calibration and Trending of Mass Spectrometer Stability
Facilitator: Rama Tummala, Agilent Technologies 
Scribe: Ewald can den Bremer, Genmab

To view notes from this discussion, click here  

 

 

Table 13: Capillary Electrophoresis-MS
Facilitator: Abigail Turner, NIST
Scribe: Xiaoying Jin, Genzyme, a Sanofi company 

To view notes from this discussion, click here

  


 

Table 14: Best Practices for Di- and Trisulfide Detection via MS
Facilitator: Jason Wood, Bruker Daltonics, Inc. 
Scribe: Li Zang, Biogen 

To view notes from this discussion, click here  

 


 

Table 15: What Should be Reported Considering with the Sensitivity of the Machines These Days?
Facilitator: 
Michael Boyne, BioTechLogic, Inc. 
Scribe: Sarah Rogstad, CDER, FDA

To view notes from this discussion, click here  

 

 

 

 

 

 

 

 

 


 

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