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DC Area Scientific Discussion Group - May 2020
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Virtual Meeting

Thursday, May 28, 2020 (3:00PM - 5:30PM EDT)



We invite you to join us for an afternoon of discussion on


Process Analytical Technology

 

Featured Speakers:

Water Proton NMR as Contact-free In-line PAT 

 

Bruce Yu
University of Maryland

Water is a common solvent in pharmaceutical manufacturing. Water emits an intense NMR signal through its two protons. Because water interacts with solutes dissolved in it, the 1H2O NMR signal is sensitive to solute chemistry. This forms the basis of using 1H2O NMR as a PAT for pharmaceutical manufacturing. 1H2O NMR measurements can be carried out using benchtop instruments in real time in a contact-free manner, under both static and flow conditions. Examples of 1H2O NMR in assessing protein aggregation, monitoring drug degradation, and verifying content uniformity, will be presented.


Dr. Bruce Yu is a Professor of Pharmaceutical Sciences, and Director of the Bio- and Nano-Technology Center at the University of Maryland School of Pharmacy. Dr. Yu has conducted research on proteins, imaging agents and biomaterials. His current focus is on non-destructive analytics for biologics and complex drug products, for manufacturing and quality control. He received the 2004 Kimmel Scholar Award and the 2005 US Presidential Early Career Awards for Scientists and Engineers. He received a B.S. in biochemistry from Peking University and a Ph.D. in molecular biophysics from the Johns Hopkins University.

Process Analytical Technology for API Process Understanding and Control

Charles Goss
GlaxoSmithKline

The need to fully understand and control the synthetic process for active pharmaceutical ingredients (APIs) becomes increasingly important as projects progress in scale from lab to pilot plant to manufacturing. Process Analytical Technology (PAT) enables online measurement of important process parameters during the API synthesis. This talk will illustrate applications of PAT such as NIR, IR, Raman, FBRM, UV-Vis, and MS to improve process understanding and control of API unit operations such as reaction, distillation, crystallization and drying.
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Charles Goss is a Scientific Leader in Medicinal Science and Technology at GlaxoSmithKline. He provides analytical chemistry support to cross-functional drug development teams responsible for supplying the active pharmaceutical ingredient and formulated drug products used in pre-clinical and clinical studies. He serves as a technical resource in several areas such as process monitoring, separation sciences, electrochemistry, microscopy and new analytical technologies. He received a B.A. in chemistry from Cornell University and a Ph.D. in chemistry from the University of California at Berkeley.


 

Pre-registration is required; there will be no onsite registration.



 

 

 
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