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News & Press: General News

HOS 2019 Poster Winner Announced

Monday, April 15, 2019   (0 Comments)
Posted by: Gabi Barragan
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Ingrid Grunert, with Roche Roche Diagnostics GmbH, had the winning poster at the 8th International Symposium on the Higher Order Structure (HOS), which concluded on April 10. Congratulations!

Ingrid's poster, "Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions" can be seen here
 
"I am very thankful and honored to receive this recognition by the CASSS HOS community and I also want to thank the whole team that contributed to this work!" said Ingrid.
 
"Our study assessing the chemical degradation of trastuzumab in vitro and in vivo demonstrates that chemical modifications occur faster in vivo compared to levels observed for bio-process and real-time storage conditions – and can be predicted by in vitro PBS incubation studies.These results hence question the rationality of extreme monitoring of low level alterations as critical patient safety parameters in product quality control testing. Altogether, this reflects the importance of better understanding biological degradation in vivo."
 
 To read Ingrid's abstract, click here

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