Higher Order Structure 

Home / Meetings and Events / Multi-day Symposiums / Higher Order Structure 

International Symposium on the Higher Order Structure of Protein Therapeutics

Protein higher-order structure (HOS) and dynamics are essential to protein function. For protein-based therapeutic products, HOS is a critical quality attribute which needs to be monitored to ensure safety and efficacy of drug products. HOS can be monitored by a multitude of biophysical and structural characterization tools. The choice of the appropriate biophysical method and the method development and qualification strategies to characterize and control HOS at different stages of the product lifecycle are a matter of interest and debate for a wide range of audiences.

Reasons to Attend HOS:

  • Phase-appropriate application of biophysical methods for HOS characterization during development, comparability, or biosimilarity exercises
  • The theory and practice of biophysics and the application of HOS in a molecular discovery setting
  • HOS case studies from academia, government agencies, and industry
  • Biophysical method qualification, validation, and specification-setting strategies
  • HOS characterization of new modalities (adeno-associated viruses, bioconjugates, bispecific antibodies, etc...)

For all event information, visit the Higher Order Structure Site


Click on the tab titles below to view Speaker Presentations and Roundtable Notes from the most recent meeting. 



Join us in-person or virtually from anywhere in the world for HOS 2022. Registration is open.

Image with text 'HOS 2022 Because Structure Matters April 4-6 Gaithersburg, MD'


Review Resources

Want to revisit a keynote presentation? Missed important details that may impact your work?

Visit Papers and Presentations to access relevant presentations, summary papers, and roundtable notes.