Higher Order Structure 

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International Symposium on the Higher Order Structure of Protein Therapeutics

Protein higher-order structure (HOS) and dynamics are essential to protein function. For protein-based therapeutic products, HOS is a critical quality attribute which needs to be monitored to ensure safety and efficacy of drug products. HOS can be monitored by a multitude of biophysical and structural characterization tools. The choice of the appropriate biophysical method and the method development and qualification strategies to characterize and control HOS at different stages of the product lifecycle are a matter of interest and debate for a wide range of audiences.

Reasons to Attend HOS:

  • Phase-appropriate application of biophysical methods for HOS characterization during development, comparability, or biosimilarity exercises
  • The theory and practice of biophysics and the application of HOS in a molecular discovery setting
  • HOS case studies from academia, government agencies, and industry
  • Biophysical method qualification, validation, and specification-setting strategies
  • HOS characterization of new modalities (adeno-associated viruses, bioconjugates, bispecific antibodies, etc...)

For more information, contact Symposium Manager Carolyn Slade.


Click on the tab titles below to view Speaker Presentations and Roundtable Notes from the most recent meeting. 


View On Demand Content

To view the content, visit https://casss.digitellinc.com, login to your account, and select the meeting from the list of past events. Visit the On Demand Presentations and Speaker Slides tab to view available content.

For 2021 meetings, content will be available for one year after the program. For 2022 and beyond, content will be available for three months.

Thank You for Joining Us!

We appreciate your participation in HOS 2022. Registration is closed.

Image with text 'hos 2022 because structure matters april 4-6 virtual symposium'


Review Resources

Want to revisit a keynote presentation? Missed important details that may impact your work?

Visit Papers and Presentations to access relevant presentations, summary papers, and roundtable notes.