Thursday, March 31, 2011

CASSS began as a local, non-profit chromatography discussion group in the SF Bay Area. Although its offerings have now grown to include multiple North American and international scientific symposia and boasts members from around the globe, CASSS still provides local educational and networking opportunities for separation scientists in Northern California.

March 31, 2011 Forum - Achieving Good Column Performance!

The Choice of a Reversed: Phase Column- Lloyd Snyder
The selection of a column is mainly of interest in method development, where selectivity - rather than efficiency - is the primary question. Means for comparing column selectivity will be reviewed, and several applications of one such procedure (the hydrophobic-subtraction model) will be shown. The importance of predictable column selectivity in Quality by Design (QbD) will be emphasized.

When Good Columns Go Bad!- Tom Jupille
Selecting a good column with favorable selectivity is what a mathematician might call a "necessary but not sufficient" condition for developing a good method. In reversed phase chromatography, there are six ways to control selectivity. In this section we will explore the other five from three points of view: